Two hundred years after Mary Shelley's novel the brilliant but mad Doctor (Thomas Kretschmann) has sustained his creature and himself over two centuries through genetic experimentation. In present-day America Detective O'Connor (Parker Posey) is investigating a series of horrific murders which leads her to the doctor and his creature. What she uncovers reveals the strange evolution the doctor and his creation undergo over the course of two centuries and the divergent paths creator and monster take in pursuing good or evil. 在瑪麗·雪萊的小說兩百年後，才華橫溢但瘋狂的醫生使他自己和他的怪物從兩個世紀前的當初的實驗一直幸存下來。如今，美國探員 O'Connor 在調查系列謀殺案時，被引向了醫生和他的怪物，並揭露出在長達兩個多世紀的漫長歲月中，醫生和他作品間的奇特演變和他們踏上善與惡的不同道路。